同位素2011，Vol.24Issue(1)：34-38,5.
125I粒子组织间植入近距离治疗恶性肿瘤
Investigation on Curative Efficacy for Malignant Tumor by Implantation 125Ⅰ Permanent Brachytherapy Seeds
摘要
Abstract
Twenty inpatients suffered from malignant tumors with twenty-four lesions were treated with 125Ⅰ permanent brachytherapy seed in Peking University Shenzhen Hospital, and the feasibility, curative effect and adverse effect of the treatment were observed. Before 125I seeds implantation, the three-dimensional treatment planning was preconcerted. There were two methods to implant 125Ⅰ seeds. One was to insert the seeds in the location of residual focus and metastatic lesions of the tumors directly in ordinary operations or through laparoscopy under general anesthesia. The other was to implant the seeds into the tumors through percutaneous needles by the guidance of CT scanning or color doppler ultrasonography under local anesthesia. The implantations for all of the 20 patients (24 lesions) were performed successfully. During and one week after the implantation, the distributions of the planted seeds were approximately the same as the scheduled three-dimensional treatment planning, and no seed migration was found. Adverse reactions during and after the operation were slight and recovered after correlative treatments. Clinical symptoms were palliated and serum tumor marker decreased to a different extent among most patients. The complete remission (CR) rate is 20.00％ ( 4/20 patients ),the partial remission(PR) rate is 35.00％( 7/20 patients),the stable disease (SD) rate is 30.00 ％ ( 6/20 patients ), the progressive disease (PD) rate is 15.00％ (3/20 patients), and the overall response rate (CR+PR) is 53.33％ ( 8 patients). 125Ⅰ seeds implantation for targeted therapy is convenient, safe and effective on malignant tumor, and is well worth advanced application.关键词
125I粒子/近距离放射疗法/恶性肿瘤Key words
125Ⅰ seeds/ brachytherapy/ malignant tumor分类
医药卫生引用本文复制引用
胡疏,成先义,高宙,尹为华,孙德胜,陈俊辉,贾少微..125I粒子组织间植入近距离治疗恶性肿瘤[J].同位素,2011,24(1):34-38,5.基金项目
卫生部科技发展中心"瘤内免疫靶向放疗联合微波消融技术治疗肺癌的临床研究"资助项目(W2009BX045) （W2009BX045）
