中国肺癌杂志2011，Vol.14Issue(3)：205-210,6.DOI:10.3779/j.issn.1009-3419.2011.03.05
hOGG1基因Ser326Cys多态性与肺癌易感性的meta分析研究
Meta Analysis of Association between Ser326Cys Polymorphism of hOGG1 Gene and Risk of Lung Cancer
摘要
Abstract
Background and objective Human 8-hydroxyguanine glycosylase (hOGGl) is one of the DNA repair genes, which can repair damaged DNA by specifically excising 8-dihydro-8-oxoguanine (8-OH-G).A considerable number of studies investigating hOGGl Ser326Cys polymorphism were in relation to various cancers.However, the association of h0 GG1 Ser326Cys polymorphism with risk of lung cancer is inconsistency The aim of this study is to assess the association of hOGG1 Ser326Cys polymorphism with risk of lung cancer by conducting a meta-analysis.Methods To identify all studies that are qualified for meta-analysis, we conducted a computerized literature search of MEDLINE database (before November, 2010).Two investigators independently extracted the data and reached a consensus on all items.Results According to our search limits, twenty-two case-control studies, including 8,575 lung cancer cases and 9,484 controls, were selected for meta-analysis.Significant heterogeneity was found among those twenty-two case-control studies, when excluding two studies that were not accorded with Hard-Weinberg Equilibrium, the remains performed well homogeneity.Compared with Ser326 genotype, Cys326 genotype can significantly increase risk of lung cancer (OR= 1.24, 95％ CI: 1.10-1.39, P＜0.001), especially in Asian ethnic population and hospital population (OR=l.28, 95％CI: 1.11-1.49; OR=l.26, 95％CI: 1.09-1.46).Conclusion The present study indicates that the hOGG1 Ser326Cys polymorphism is associated with risk of lung cancer, Cys326 genotype can significantly increase risk of lung cancer.关键词
hOGG1/肺肿瘤/易感性/Meta分析分类
医药卫生引用本文复制引用
钱乾,刘仍允,雷哲,尤嘉琮,周清华,张洪涛..hOGG1基因Ser326Cys多态性与肺癌易感性的meta分析研究[J].中国肺癌杂志,2011,14(3):205-210,6.基金项目
本研究受国家自然基金(No.30973425),教育部"新世纪优秀人才支持计划"(No.NCET-09-0165)、江苏省自然科学基金(No.BK2008162)、江苏省教育厅"青蓝工程"、江苏省人事厅"333工程"和天津市科技支撑计划中瑞合作重大项目(No.09ZCZDSP04100)资助 （No.30973425）
