实用妇产科杂志2011，Vol.27Issue(3)：194-197,4.
子痫前期胎盘抑制素A、胎盘激活素A和胎盘抑制素B基因的表达
Expressions of Placenta Inhibin-A, Activin-A and Inhibin-B Genes in Preeclamptic Pregnancy
摘要
Abstract
Objective: To investigate the mRNA expression and the significance of inhibin-A,activin-A and inhibin-B subunites in the placenta from preeclamptic patients.Methods: The mRNA levels of inhibin-A, activin-A and inhibin-B subunites in the placenta from 44 pre-eclamptic patients and 30 normal pregnancies were measured by RT-PCR.Results: The mRNA levels of inhibin-A α-βA subunite and activin-A βA-βA subunite in the placentas from pre-eclamptic patients were significantly higher than those in the placenta from normal pregnancies (P ＜ 0.05 ), while the mRNA expression of inhibin-B α-βB subunit between the preeclamptic and normal pregnancy groups were no significant difference( P＞0.05).Conclutions: The mRNA levels of inhibin-A α-βA subunite and activin-A βA-βA subunite increased significantly in the placenta from pre-eclamptic patients.The levels of inhibin-A and activin-A can reflect the function of trophoblastic cells, so they could be useful markers to monitor the function of placenta, and involve in the pathophysiologic process of preeclampsia.关键词
子痫前期/胎盘/抑制素A/激活素A/抑制素B分类
医药卫生引用本文复制引用
董旭东,吴云萍,江江,陈桂仙..子痫前期胎盘抑制素A、胎盘激活素A和胎盘抑制素B基因的表达[J].实用妇产科杂志,2011,27(3):194-197,4.基金项目
云南省中青年学术技术带头人后备人才资助项目(编号:2008PY045) （编号:2008PY045）
