中国组织工程研究与临床康复2011，Vol.15Issue(18)：3255-3258,4.DOI:10.3969/j.issn.1673-8225.2011.18.007
盐酸戊乙奎醚对原位肝移植后急性肺损伤的保护效应
Protective effects of penequinine hydrochloride on acute lung injury induced by orthotopic liver transplantation
司建洛 1宋绍团 1昌盛2
作者信息
- 1. 河南科技大学第一附属医院麻醉科,河南省洛阳市471003
- 2. 华中科技大学同济医学院附属同济医院器官移植研究所,湖北省武汉市430030
- 折叠
摘要
Abstract
BACKGROUND: Penequinine hydrochloride can alleviate inflammatory response and protect against cell injury, but therapeutic effects were uncertainty on acute lung injury after orthotopic liver transplantation.OBJECTIVE: To evaluate protective efficacy of intravenous penequinine hydrochloride on acute lung injury after orthotopic liver transplantation .METHODS: Thirty-five patients with acute lung injury after orthotopic liver transplantation were randomly assigned to 2 groups:treatment group (n=l7) and control group (n=18). On the base of routine comprehensive therapy, the patients received intravenous infusion with 0.05 mg/kg penequinine hyd rochloride once a day for 3 days in the treatment group or with normal saline of same volume in the control group. Plasma interleukin (IL)-8, and IL-10 were measured and index of oxygenation was calculated before and 24, 72 hou rs after the treatment. Length of mechanical ventilation was recorded.RESULTS AND CONCLUSION: Compared with the control group, the level of plasma IL-8 decreased significantly in the treatment group at 24 and 72 hours after the treatment, but the level of plasma IL-10 in the treatment group was significantly higher than that in the control group at the same time (P ＜ 0.05). In the treatment group, the patients' index of oxygenation was higher and length of mechanical ventilation was shorter than that in the control group (P ＜ 0.05). These findings show that penequinine hydrochloride can regulate the level of inflammatory factors in patients with acute lung injury after orthotopic liver transplantation, improve arterial oxygenation and shorten the length of mechanical ventilation.关键词
盐酸戊乙奎醚/原位肝移植/急性肺损伤/白细胞介素8/白细胞介素10分类
临床医学引用本文复制引用
司建洛,宋绍团,昌盛..盐酸戊乙奎醚对原位肝移植后急性肺损伤的保护效应[J].中国组织工程研究与临床康复,2011,15(18):3255-3258,4.
