中国组织工程研究与临床康复2011，Vol.15Issue(18)：3337-3340,4.DOI:10.3969/j.issn.1673-8225.2011.18.026
肾移植受者血清sFas和sFasL变化及在早期急性排异反应预测中的应用
Changes in serum soluble Fas and soluble Fas ligand of renal graft recipients in early period post-transplant as a predictor of acute renal allograft rejection
宋洁 1李辉 1张晓东 1李瑛1
作者信息
- 1. 武警医学院附属医院肾病科,天津市,300162
- 折叠
摘要
Abstract
BACKGROUND: Apoptosis of target cells plays a crucial effect on acute rejection after organ transplantation. Fas/Fas ligand (FasL) system is considered as one of action pathways of acute rejection after organ transplantation.OBJECTIVE: To study the serum soluble Fas and soluble FasL levels of renal graft recipients in early post-transplant period and their application as a predictor of acute renal allograft rejection.METHODS: The sequential monitoring of serum soluble Fas and soluble FasL levels in 80 patients was conducted by ELISA technique before and after renal transplantation and the relationship between sFas/sFasL with acute renal allograft rejection were analyzed.RESULTS AND CONCLUSION: The levels of serum soluble Fas and soluble FasL in the patients for renal transplantation were significantly higher than that in control before operation (P ＜ 0.05). The levels of serum soluble Fas and solu ble FasL in acute rejection group at same time were significantly higher than that in normal group after operation (P ＜ 0.05), and compared with that in CsA-induced nephrotoxicity group, there was no significant difference. The sequential monitoring of serum solu ble Fas and soluble FasL in renal allograft recipients may be of a useful value to make early and differential diagnosis of acute renal rejection.关键词
可溶性Fas/肾移植/急性排异反应/可溶性Fas/配体/器官移植分类
医药卫生引用本文复制引用
宋洁,李辉,张晓东,李瑛..肾移植受者血清sFas和sFasL变化及在早期急性排异反应预测中的应用[J].中国组织工程研究与临床康复,2011,15(18):3337-3340,4.
