中国临床医学2011，Vol.18Issue(2)：201-204,4.
宫颈疾病液基细胞学和人乳头状瘤病毒脱氧核糖核酸联合检测及与组织学检查的对照研究
A Study of Thinprep Cytologic Test Combined with Human Papilloma Virus Hybrid CaptureⅡ DNA Test and Biopsy-Control in Cervical Lesions
摘要
Abstract
Objective:To investigate the value of thinprep cytologic test(TCT) combined with human papilloma virus (HPV)Hybrid Capture Ⅱ( HPV HCⅡ) test in cervical intraepithelial neoplasia and summarize the reasons for misinterpreting/missing diagnosis.Methods:Patients(n = 1050) with TCT, HCⅡ HPV test and routine biopsy under colposcopy encountered between 2006-2009 in Shanghai Changning District hospital.According to cervical biopsy diagnosis, we analyzed the causes of false-positive and false-negative in TCT diagnosis and compared the diagnostic efficiency among TCT, HCⅡ HPV test, TCT combined with HCⅡ HPV test.Results: The rates of (LSIL/HSIL) accordance with biopsy were higher than (NILM/ASCUS),P＜0.01.HPV infection was increased with the degree of cervical lesions(P＜0.01).The sensitivity and negative predictive value were significantly higher for TCT combined with HCⅡ HPV DNA than TCT alone(P＜0.01 ).The causes of false-positive in TCT diagnosis were mainly for misinterpreting reactive cells and regressive cells while false-negative were mainly for missing individual koilocyte and dysplastic cell.Conclusions: TCT combined with HCⅡ HPV test evidently enhance diagnostic efficiency which will play a positive role in the early preventation, detection and treatment of cervical carcinoma.False-positive and falsenegative will be effectively decreased by means of accurate sampling, regular procession and exact recognization of reactive cell,koilocyte and hyperchromaticly dysplastic cell.关键词
薄层液基细胞学检查/第2代杂交捕获乳头状瘤病毒脱氧核糖核酸检测/联合试验/宫颈上皮内瘤变分类
医药卫生引用本文复制引用
陶琨,杨静,杨华,郭振华,陈向宇,孟晓彦,王春蕾,唐龙英,左绪磊..宫颈疾病液基细胞学和人乳头状瘤病毒脱氧核糖核酸联合检测及与组织学检查的对照研究[J].中国临床医学,2011,18(2):201-204,4.基金项目
上海市长宁区卫生局资助项目(编号:2005101002) （编号:2005101002）
