中国临床医学2011，Vol.18Issue(2)：243-245,3.
不同麻醉方法对单核细胞mCD14与TLR4表达的影响
Effects of Different Anaesthesia Methods on Expression of Monocyte mCD14 and TLR4
孙霞 1方浩 2缪长虹2
作者信息
- 1. 复旦大学附属肿瘤医院麻醉科,上海,200032
- 2. 复旦大学附属中山医院麻醉科,上海,200032
- 折叠
摘要
Abstract
Objective: This study was designed to investigate the effects of different anaesthesia methods on expression of monocyte mCD14 and TLR4. Methods: A total of 24 ASA Ⅰ or Ⅱ, BMI 18-23kg/m2 , 18-65 year-old patients, who were scheduled for radical treatment of colon or rectum carcinoma were recruited in this study. They were randomly allocated to receive general anaesthesia (Group GA, n= 12) or general anaesthesia combined with epidural anaesthesia (Group GA+ E, n= 12). Patients in Group GA were induced with 1.5-2.0 mg/kg propofol and 6μg/kg fentanyl, and tracheal intubation was accomplished with 0. 6-0. 8mg/kg rocuronium.The anaesthesia was maintained with sevoflurane (end-tidal concentration 1.0-1.3MAC). Patients in Group GA + E were placed an epidural catheter at a vertebral interspace between T12 and L1. General anaesthesia was performed as Group GA. After administration 1 ％lidocaine and 0.2 ％ tetracaine 9-12ml, anaesthesia was maintained with sevoflurane, the end-tidal concentrations were 0.6-0. 8 mininum alveolar concentration(MAC), and epidural infusion of 1％ lidocaine and 0.2 ％ tetracaine 3-4ml/h. 2ml peripheral vein blood was collected from every patient before operation, at the beginning of operation, 2 hours after the beginning of operation and 24 hours after the end of operation, respectively. Perioperative express of monocyte mCD14 and Toil-like receptor 4 were measured. Results: Compared with Group GA + E, Group GA had no effects on the expression of monocyte mCD14 at different time points. Epidural anesthesia can prevent the depression of monocyte TLR4(P＜0. 05). Conclusions: Epidural anaesthesia may have benefitial effects on immune reaction and stress response induced by surgical stress.关键词
单核细胞/mCD14/TLR4分类
医药卫生引用本文复制引用
孙霞,方浩,缪长虹..不同麻醉方法对单核细胞mCD14与TLR4表达的影响[J].中国临床医学,2011,18(2):243-245,3.
