安徽医科大学学报2011，Vol.46Issue(6)：545-548,4.
盐酸贝那普利对糖尿病大鼠肾脏IGF-1表达及相关因素的影响
Effect of benazepril hydrochloride on IGF-1 expression and related factors in diabetic rats
陈玉米 1任伟 1叶山东 2邢燕 2汪鹏 1胡圆圆 2胡闻 3陈柯 3陈燕4
作者信息
- 1. 安徽医科大学附属省立医院肾脏内科,合肥,230001
- 2. 安徽医科大学附属省立医院内分泌科,合肥,230001
- 3. 安徽医科大学附属省立医院病理科,合肥,230001
- 4. 安徽医科大学附属省立医院内分泌实验室,合肥,230001
- 折叠
摘要
Abstract
Objective To investigate the renoprotective effects of benazepril hydrochloride and its possible mechanisms. Methods 30 Sprague-Dawley( SD )rats were assigned to normal control( group NC,n = 8 )and model group.Streptozotoin( STZ )-induced diabetic model rats were then treated with( group DM )or without benazepril( group DT ). Peripheral blood glucose was tested weekly in all groups. At the end of the 4th week.blood glucose, HbAlc,urinary insulin-like growth factor-l( IGF-1 ), urinary albumin, and urinary retinol-binding protein were tested. The renal tissues of diabetic rats were obtained after the rats sacrificed to observe the structure changes under electron microscope and IGF-1 expression was observed by immunohistochemistry. Results At the end of the 4th week.compared with those in group NC, all indexes measured above and the relative kidney index were markedly increased in group DM ( P ＜ 0. 01 ). The renal pathological lesions of rats in group DM were obvious. Benazepril treatment could significantly decrease the above parameters( P＜0. 01 )and lessen the renal pathological lesions in comparison with those in group DM except for the blood glucose and HbAlc. Conclusion Benazepril exerts renoprotective effect via inhibiting the overexpressed IGF-1 in local kidney of diabetic rats.关键词
糖尿病/糖尿病肾病/胰岛素样生长因子Ⅰ分类
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陈玉米,任伟,叶山东,邢燕,汪鹏,胡圆圆,胡闻,陈柯,陈燕..盐酸贝那普利对糖尿病大鼠肾脏IGF-1表达及相关因素的影响[J].安徽医科大学学报,2011,46(6):545-548,4.
