国际医药卫生导报2011，Vol.17Issue(10)：1205-1208,4.DOI:10.3760/cma.j.issn.1007-1245.2011.10.019
持续小剂量肝素治疗严重脓毒症的疗效分析
Clinical efficacy of continuous low-dose heparin in the treatment of severe sepsis
张振辉 1刘卫江 1杨其霖 1谢富华 1熊旭明1
作者信息
- 1. 510260,广州,广州医学院第二附属医院危重病学科
- 折叠
摘要
Abstract
Objective To investigate the therapeutic effects of continuous low-dose heparin on severe sepsis.Mehoda 67 severe septic patients were randomly divided into tow groups:routine treat-ment group(n=36)and heparin treatment group(n=31).The levels of platelet(PET)count,APTr,PT,FIB and AT-Ⅲ were determined before and after treatment in two groups.The days of mechanical ventilation and the incidence nltes of disseminated intravascular coagulopathy(DIC),acute renal failure(ARF),acute respiratory distress syndrome(ARDS),multiple organ dysfunction syndrome(MODS),The 7-day and 28-dav mortalitv were observed.Results There are significant differences for the incidence rate of ARDS,DIC.MODS and 28-day mortality between routine treatment group and heparin treatment group(P＜0.05).And there are no siguificant differences for the levels of PLT count,APTT,PT,FIB,AT-Ⅲ,the days of mechanical ventilation,the incidence rate of ARF,7-day mortality between routine treatment group and heparin treatment group (P>0.05).Conclusion Continuous low-dose heparin on severe sepsis was sale relatively,and it could improve the prognosis and decrease the mortality rate of severe septic patients.关键词
肝素/脓毒症/严重脓毒症Key words
Heparin/Sepsis/Severe sepsis引用本文复制引用
张振辉,刘卫江,杨其霖,谢富华,熊旭明..持续小剂量肝素治疗严重脓毒症的疗效分析[J].国际医药卫生导报,2011,17(10):1205-1208,4.
