摘要
Abstract
Objective To investigate the effect of Alfacalcidol on microinflammation in the patients with type 2 diabetic nephropathy. Methods Totally 70 type 2 diahetic nephropathy patients in our hospital were enrolled. All patients were randomly divided into treatment group ( 21 males and 14 females ) and control group ( 22 males and 13 females ) . While twenty healthy adults were selected as healthy group. Patients in treatment group received Alfacalcidol and routine drug therapy for 12 weeks while patients in control group took routine drug therapy only. Healthy control group took no medicines. Serum hs - CRP, IL - 6, TNF -α. albumin, prealbumin, fasting blood sugar ( FBS ), creatinine , and 24 - hour urine protein were measured at baseline and 12 weeks later. Results Compared with the healthy group, the serum hs - CRP, 11 -6, TNF - α level and 24 h urine protein were significantly increased ( P ＜ 0. 05 ) and serum prealbumin significantly decreased ( P ＜ 0. 05 ) both in treatment group and control group. Compared to the baseline values, the hs - CRP, IL - 6, TNF - α level and 24 h urine protein were significantly decreased ( P ＜0. 05 ) and serum prealbumin significantly increased ( P ＜ 0. 05 ) in treatment group after 12 weeks, and there were significant differences between treatment group and control group ( P ＜ 0. 05 ) . Serum creatinine, FBS, and albumin showed no significant difference between treatment group and control group either at baseline or after 12 weeks ( P ＞0. 05 ). Conclusion Microinflammation exists in the patients with type 2 diabetic nephropathy. Alfacalcidol can ohviously improve the microinflammation, alleviate proteinuria, and improve nutrition status.关键词
阿法骨化醇/糖尿病肾病/微炎症状态分类
医药卫生
