中国全科医学2011，Vol.14Issue(15)：1710-1712,3.
TAC与CAF方案应用于乳腺癌新辅助化疗的疗效和安全性研究
Comparison of the Efficacy and Safety of TAC and CAF Regimens as Neadjuwant Chemotherapy for Breast Cancer
赵世韬 1杜红阳1
作者信息
- 1. 121001,辽宁省锦州市,辽宁医学院附属第一医院乳腺外科
- 折叠
摘要
Abstract
Objective To compare the efficacy and safety of TAC regimen vs CAF regimen as neoadjuvant chemotherapy for breast cancer. Methods Totally 74 patients with pathologically confirmed breast cancer were randomly divided into CAF group ( n = 37 ) and TAC group ( n = 37 ) . Patients in each group received surgery after two cycles of neoadjuvant chemotherapy ( each cycle lasted 21 days ) , and the efficacy and safety were compared. Results No patient withdrew from the study due to the side effect. No disease progression was noted. The numbers of patients who got complete response ( CR ) , partial response ( PR ),stable disease ( SD ) were 4. 27 , and 6 in TAC group and 2, 21, and 14 in CAF group ( P ＜ 0. 05 ) . The incidences of leucopenia, granulocytopenia, and hair loss showed significant differences between these two group ( P ＜ 0. 01 ), while those of thrombocytopenia, nausea/vomiting, and cardiac toxicity were not significantly different ( P ＞ 0. 05 ) . Conclusion Both TAC and CAF are effective for the treatment of breast cancer. As a neoadjuvant chemotherapy, compared with CAF, TAC has better effectiveness and lower toxic effects.关键词
TAC/CAF/乳腺肿瘤/新辅助化疗分类
医药卫生引用本文复制引用
赵世韬,杜红阳..TAC与CAF方案应用于乳腺癌新辅助化疗的疗效和安全性研究[J].中国全科医学,2011,14(15):1710-1712,3.
