中国肿瘤生物治疗杂志2011，Vol.18Issue(2)：115-125,11.DOI:10.3872/j.issn.1007-385X.2011.02.001
肿瘤休眠细胞:复发根源和治疗靶标
Dormant tumor cells:Root for recurrence and target for therapy
摘要
Abstract
With the fast development of early diagnosis and treatment for cancers, the survival rates of victims of this deadly disease has been greatly increased.Yet the survivors still face the threat of reoccurrence.More and more evidence documented that these disease-free patients ( and even some so-called healthy people) harbor dormant tumor cells, which are now regarded as the main cause for tumor reoccurrence.Dormant tumor cells refer to a group of cells featured by its minimal number and the inconvenience for detection.These cells are caught in cell cycle arrest and can exist in both patients and healthy people.At present, the mechanism of how these cells are formed and dormancy timing patterns are still unknown.As the bone marrow and peripheral blood of patients are easy obtained, sensitive detection method has been established aimed to detect dormant tumor cells from these two sources.Evidence has shown that immunological suppression,angiogenesis in tumor tissues as well as surgery may all play roles in tumor dormancy activation, and thus lead to tumor reoccurrence and metastasis.As a result, dormant tumor cells have become a crucial target for preventing and treating cancers.However, since dormant tumor cells stay in a tranquil state, they are insensitive to traditional clinical therapies including radiation treatment and chemotherapy, and therefore impose great difficulty for the radical cure.According to the latest research, immune surveillance is closely related to the phenomena of tumor dormancy.As a result, adoptive immunotherapy may bring radical revolution in the area of tumor prevention and treatment.We hope that, with the deepening of research on tumor dormancy, clinical options with high efficiency will be available to wipe out tumor cells or induce tumor cells into permanent dormancy.关键词
肿瘤/肿瘤休眠细胞/复发/转移/过继细胞治疗/治疗靶标分类
医药卫生引用本文复制引用
钱其军,刘新垣..肿瘤休眠细胞:复发根源和治疗靶标[J].中国肿瘤生物治疗杂志,2011,18(2):115-125,11.基金项目
国家杰出青年科学基金资助项目(No.30925037) （No.30925037）
艾滋病和病毒性肝炎等重大传染病防治重大科技专项基金资助项目(No.2008ZX10002-023). （No.2008ZX10002-023）
