中国全科医学2011，Vol.14Issue(18)：2043-2045,3.
盐酸罂粟碱对于常规治疗无效的结石引发急性肾绞痛疗效观察
Therapeutic Effect of Papaverine Hydrochloride in Acute Calculus-caused Renal Colic Unresponsive to Conventional Treatment
郭建 1丁宁 1陈晓雄1
作者信息
- 1. 100730,北京市,首都医科大学附属北京同仁医院急诊外科
- 折叠
摘要
Abstract
Objective To evaluate the therapeutic effect of papaverine hydrochloride in calculus - caused acute renal colic unresponsive to conventional treatment.Methods Eighty calculus - caused acute renal colic patients unresponsive to conventional treatments in Emergency Department of Beijing Tongren Hospital from 2004 to 2007 were divided randomly into groups Ⅰ ( given intravenous Raceanisodamine Hydrochloride and Aspirin - Dl - Lysine ), Ⅱ ( given intravenous papaverine hydrochloride ), Ⅲ ( given intravenous pethidine ).Pains were assessed by vision analog score ( VAS ) in all patients before or after treatment.Results After 1 h of treatment, VAS was significantly lower in groups Ⅱ, Ⅲ (1.05 ±0.23, 0.98 ±0.40, respectively ) than in group Ⅰ ( 3.74 ±2.45 ), the difference was significant ( P ＜0.05 ), but there was not between groups Ⅱ , Ⅲ ( P ＞0.05 ).No obvious adverse reactions were noted in groups Ⅰ , Ⅱ , but in group Ⅲ, mild or moderate sedation noted in 9 patients, mild bradycardia and hypotension in 2.Four hours after treatment 6 patients still had severe renal colic ( VAS ＞ 7 ), 5 of them improved after extracorporeal shock wave lithotripsy ( ESWL ), 1 was hospitalized to undergo emergency renal fis-tulization due to ineffective ESWL.Conclusion Papaverine hydrochloride, remarkably effective to calculus - caused acute renal colic unresponsive to conventional treatment, can be used as a substitute for anesthesia drugs such as pethidine.关键词
肾结石/绞痛/罂粟碱分类
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郭建,丁宁,陈晓雄..盐酸罂粟碱对于常规治疗无效的结石引发急性肾绞痛疗效观察[J].中国全科医学,2011,14(18):2043-2045,3.
