青岛大学医学院学报2011，Vol.47Issue(3)：235-236,239,3.
CMV感染新生儿尿DNA含量和血T细胞亚群变化
CHANGES OF DNA CONTENT IN URINE AND T CELL SUBSETS IN BLOOD OF NEONATES WITH CYTOMEGALOVIRUS INFECTION
牟文凤 1苏乃伦 1李海峰 1蒋玉红 1王斌2
作者信息
- 1. 青岛市妇女儿童医疗保健中心检验科,山东,青岛,266011
- 2. 青岛大学医学院微生物学教研室
- 折叠
摘要
Abstract
Objective To investigate the changes and significance of DNA content in urine and T cell subsets in blood of neonates infected with cytomegalovirus (CMV).Methods Forty-three neonates who were confirmed infected by CMV were selected in this study: 20 cases were symptomatic, and 23 asymptomatic.Sixteen newborns who received health examination served as controls.The DNA content in urine and T cell subsets in blood were detected.The sick neonates were followed up.Results The urine DNA level in symptomatic sick neonates was higher than that in the asymptomatic, the difference being significant (t=3.698,P＜0.01).Blood levels of CD3+ , CD4+ and CD4+/CD8+ in the symptomatic group were lower than that in the asymptomatic and healthy controls, while the levels of CD8+ were higher (F=3.74-42.34;q=3.21-11.76sP＜0.05,0.01).Follow-up revealed that of the symptomatic sick neonates, six of them showed persistent T cell subsets, accompanying abnormal liver functions, of whom, urine DNA elevated in four cases and which was kept at a higher level.Conclusion Marked changes of urine DNA and blood T cell subsets were observed in symptomatic CMV-infected neonates, which is of significance in prediction of prognosis and in guidance of clinical therapy for this condition.关键词
婴儿,新生/巨细胞病毒感染/T淋巴细胞亚群Key words
infant, newborn/ cytomegalovirus infection/ T-lymphocyte subsets分类
医药卫生引用本文复制引用
牟文凤,苏乃伦,李海峰,蒋玉红,王斌..CMV感染新生儿尿DNA含量和血T细胞亚群变化[J].青岛大学医学院学报,2011,47(3):235-236,239,3.
