军医进修学院学报2011，Vol.32Issue(5)：423-425,3.DOI:CNKI:11-3275/R.20110303.0821.000
缓释氟尿嘧啶在腹腔镜直肠癌根治术中的安全性及疗效
Safety and curative efficacy of sustained-release fluorourancil during radical laparoscopic surgery of rectal carcinoma: Clinical observations
摘要
Abstract
Objective To study the safety and curative effect of sustained-release fluorourancil during laparoscopic rectal carcinoma surgery. Methods One hundred and seventy-two patients with rectal carcinoma who underwent laparoscopic radical surgery in our department from March 2006 to January 2009 were divided into observation group(n=90) and control group(n=82). Patients in observation group received regional chemotherapy with sustained-release fluorourancil under laparoscope. Patients in control group did not receive regional chemotherapy with sustained-release fluorourancil under laparoscope. Their outcomes were retrospectively analyzed. Results No difference was found in liver and kidney functions and white blood cell count between the two groups before and after operation(P>0.05). The local recurrence rate of rectal carcinoma was l.ll%(l/90) and 7.78%(7/90) respectively in observation group, and 8.54%(7/82) and 17.07%(14/82) respectively in control group 1 and 2 years after operation(P<0.05). The liver metastasis rate was 5.55%(5/90) and 17.78%(16/90) respectively in observation group, and 15.85%(13/82) and 26.83%(22/82) respectively in control group 1 and 2 years after operation(P<0.05). Conclusion Sustained-release fluorourancil is effective and safe as a regional chemotherapy agent for rectal carcinoma during laparoscopic radical surgery, and can reduce its local recurrence and liver metastasis.关键词
腹腔镜/直肠癌/缓释化疗Key words
Laparoscopes/ Rectal Cancer/ Sustained-Release Chemotherapy分类
医药卫生引用本文复制引用
李松岩,陈凛,宁宁,许声江,李荣,杜晓辉..缓释氟尿嘧啶在腹腔镜直肠癌根治术中的安全性及疗效[J].军医进修学院学报,2011,32(5):423-425,3.基金项目
军队"十一五"科技攻关项目(06G107) （06G107）
北京市科技新星计划课题(2006A51) （2006A51）
