军医进修学院学报2011，Vol.32Issue(5)：428-429,466,3.DOI:CNKI:11-3275/R.20101208.1524.001
探讨糖化血清蛋白和糖化白蛋白在糖尿病高危人群的最佳切点
Optimal cut point of glycosylated serum protein and glycated albumin in diagnosis of diabetes mellitus in high risk populations
郑华 1贾春晖 1马芳玲 1汪保安 1邹效漫 1母义明1
作者信息
- 1. 解放军总医院内分泌科,北京,100853
- 折叠
摘要
Abstract
Objective To study the optimal cut point of receiver operating characteristic(ROC) curves for glycosylated serum protein (GSP), glycated albumin(GA-L) and fasting plasma glucose(FPG) when glycated hemoglobin(HbAlc) was used in diagnosis of diabetes mellitus(DM). Methods ROC curves were plotted for 88 patients(54 males and 34 females) with suspicious DM diagnosed following the 2010 American Diabetes Association(ADA) diagnostic criteria. The optimal cut point, sensitivity and specificity of GSP, GA-L and FPG in diagnosis of DM were comparatively analyzed. Results The optimal cut point of ROC curves for GSP in diagnosis of DM was 186.1μmol/L, with a sensitivity of 55%, a specificity of 98%, area of 0.804 under the curve, a positive likelihood ratio of 27.63, a negative likelihood ratio of 0.46, a positive predictive value of 95% and a negative predicative value of 74%. The optimal cut point of ROC curves for GA-L in diagnosis of DM was 16.86%, with a sensitivity of 61%, a specificity of 98%, area of 0.849 under the curve, a positive likelihood ratio of 30.26, a negative likelihood ratio of 0.40, a positive predictive value of 96% and a negative predicative value of 77%. The optimal cut point of ROC curves for FPG in diagnosis of DM was 5.67mmol/L, with a sensitivity of 58%, a specificity of 78% and area of 0.736 under the curve. Conclusion Among the GA-L, GSP and FPG, the specificity and sensitivity of GA-L are the highest in diagnosis of DM. The accuracy of GA-L in diagnosis of DM is higher than that of GSP and FPG since the area under the curve is GA-L>GSP >FPG.关键词
糖化血红蛋白/糖化血清蛋白/糖化白蛋白/空腹血糖/受试者工作特征曲线/糖尿病Key words
Glycosylated Hemoglobin/ Glycosylated Serum Protein/ Glycosylated Albumin/ Fasting Plasma Glucose/ Receiver Operating Characteristic Curve/ Diabetes Mellitus分类
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郑华,贾春晖,马芳玲,汪保安,邹效漫,母义明..探讨糖化血清蛋白和糖化白蛋白在糖尿病高危人群的最佳切点[J].军医进修学院学报,2011,32(5):428-429,466,3.
