军医进修学院学报2011，Vol.32Issue(5)：430-431,434,3.DOI:CNKI:11-3275/R.20101124.1128.001
血栓弹力图评价血小板花生四烯酸途径抑制率对血凝块形成的影响
Inhibitory effect of arachidonic acid pathway in platelets on clot formation assessed by thromboelastography
黎金庆 1周合冰 1郭金成 2单志娟 1张娟 1曾惠 1付晨晓1
作者信息
- 1. 通州区潞河医院血液科,北京,101149
- 2. 通州区潞河医院心内科,北京,101149
- 折叠
摘要
Abstract
Objective To study the inhibitory effect of arachidonic acid pathway in platelets on clot formation and its correlation with ADP receptor inhibition. Methods Eighty patients with acute coronary syndrome were treated with aspirin(l00mg) in combination with clopidogrel(75mg) daily. Inhibitory rate of arachidonic acid pathway and ADP receptor pathway in platelets were detected by thromboelastography. The following varibles of arachidonic acid channel were also recorded: a angle, K time, maximum amplitude(MA) and time to MA(TMA). Results The inhibitory rate of arachidonic acid pathway and ADP receptor pathway was 81.7% ± 20.7% and 65.9% ±253%, respectively. The α angle, MA and TMAwere(482± 15.9)° , (205 ± 142)mm and (13.8 ±75)min, respectively. The a angle became smaller, the MA decreased and the TMA became shorter with the increasing inhibitory rate of arachidonic acid pathway(P<0.05). The number of cases having no K time was increased when the K time became longer. Conclusion Inhibition of arachidonic acid pathway in platelets is not favorable for clot formation. The speed and strength of clot formation decrease with the increasing inhibitory rate of arachidonic acid pathway. The inhibition rates of arachidonic acid pathway and ADP receptor pathway are positively correlated.关键词
血栓弹力描记术/阿司匹林/氯吡格雷Key words
Thromboelastography/ Aspirin/ Clopidogrel分类
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黎金庆,周合冰,郭金成,单志娟,张娟,曾惠,付晨晓..血栓弹力图评价血小板花生四烯酸途径抑制率对血凝块形成的影响[J].军医进修学院学报,2011,32(5):430-431,434,3.
