西安交通大学学报（医学版）2011，Vol.32Issue(3)：352-354,390,4.
血管内皮生长因子和血管抑素在子宫异位和在位内膜中的表达及意义
The expressions of vascular endothelial growth factor and angiostatin in ectopic and eutopic endometrium of patients with endometriosis
彭慧霞 1王冬颖 1李兰 1尉春艳 1吴静1
作者信息
- 1. 西安交通大学医学院第二附属医院妇产科,陕西西安,710004
- 折叠
摘要
Abstract
Objective To investigate the expressions and significance of vascular endothelial growth factor (VEGF) and angiostatin (AGN) in ectopic and eutopic endometrium.Methods VEGF and AGN were immunohistochemically detected in ectopic and eutopic endometrium from 28 patients with endometriosis and in normal endometrium from 22 controls.Results The positive rates of VEGF expression in ectopic and eutopic proliferative endometrium (87.5 ％, 56.3 ％) from EMs patients were higher than those from the controls (46.7 ％).Also, the positive rates of VEGF expression in ectopic and eutopic secretory endometrium (83.3％, 75％) were higher in EMs patients than in the controls (42.9％).The differences were both significant (P＜0.05).Similarly,the positive rates of AGN expression in eutopic and ectopic proliferative endometrium (37.5％, 56.3％) from EMs patients were significantly higher than those from the controls (33.3％).The positive rates of AGN expression in eutopic and ectopic secretory endometrium (58.3％, 75％) were significantly higher in EMs patients than in the controls (28.6％) (P＜0.05).Conclusion The high expressions of VEGF and AGN in EMs tissues may be one of the mechanisms of endometriosis development.关键词
子宫内膜异位症/血管内皮生长因子/血管抑素分类
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彭慧霞,王冬颖,李兰,尉春艳,吴静..血管内皮生长因子和血管抑素在子宫异位和在位内膜中的表达及意义[J].西安交通大学学报（医学版）,2011,32(3):352-354,390,4.
