湖南中医药大学学报2011，Vol.31Issue(3)：36-38,3.
盐酸青藤碱加离子导入法对透皮吸收的影响
Effect of Sinomenine Hydrochloride with iontophoresis on transdermal permeability
摘要
Abstract
Objective To study the transdermai permeability of Sinomenine Hydrochloride and effected by ion-introduction. Method The transdermai permeability was made by skin in vitro in rabbits and Franz diffusion ceils with Electric Therapeutic Equipment as apposition electrical field to use ion-introduction, the transdermal permeation rate of Sinomenine Hydrochloride injection was measured to compare the effect of the apposition electrical field affected on the transdermai permeability. Result The transdermai permeation rate of Sinomenine Hydrochloride was increased as time going on, which conformed to zero-order equation (R2=0.952 1), and the electrical field added was increased the transdermai absorption quantum, when the electrical field was 20 mA in 15 rain, the transdermal absorption quantum was better. Conclusion Sinomenine Hydrochloride injection can be absorpted transdermally and be promoted by the electrical field,which provides an experimentation grounds for Sinomenine Hydrochloride injection using in ionintroduction in clinic.关键词
盐酸青藤碱/透皮吸收/离子导入/兔/大鼠Key words
Sinomenine Hydrochloride/ transdermai permeability/ ion-introduction/ rabbits/rats分类
医药卫生引用本文复制引用
邱赛红,李琳,朱传湘,吴红娟,藤健,谢昭明..盐酸青藤碱加离子导入法对透皮吸收的影响[J].湖南中医药大学学报,2011,31(3):36-38,3.基金项目
湖南省高等学校科研项(09C734). （09C734）
