中国全科医学2011，Vol.14Issue(16)：1785-1788,4.
冠心病经皮冠脉介入治疗患者N末端脑钠肽前体水平与冠脉病变严重程度的相关性研究
Correlation between Plasma NT-proBNP Value and Severity of Coronary Artery Diseases in Percutaneous Coronary Intervention Patients
摘要
Abstract
Objective To investigate the correlation of plasma concentration of N - terminal - pro - brain natriuretic peptide ( NT - proBNP ) in patients with coronary artery disease ( CAD ) received percutaneous coronary intervention ( PCI ) with severity of the diseases, and whether NT - proBNP is a reliable biochemical marker to correctly indicate the severity of CAD. Methods Totally 844 patients who underwent PCI because of coronary heart disease were consecutively recruited. Their plasma NT - proBNP level was determined. The patients were further divided into various subgroups according to Gensini score ,coronary arteries involved, and infarction related arteries ( IRA ). The results of plasma NT - proBNP and related indices of cardiac function were analyzed by using Analysis of Variance and x2 test. Results As the number of coronary arteries involved increased. NT - proBNP level and left atrial diameter increased, and left ventricular ejection fraction ( LVEF ) decreased; and with the increase of Gensini score, NT - proBNP levels , patient age and left ventricular end - diastolic volume ( LVEDd ) increased , ejection fraction ( LVEF ) reduced ( P ＜ 0. 05 ) . NT - proBNP level was positively correlated with age, left atrial diameter. LVED. Gensini score, and number of coronary arteries involved, and negatively correlated with LVEF ( P ＜ 0. 01 ) . Conclusion Plasma concentration of NT - proBNP in patients with CAD is of a certain correlation with the severity of the disease,which might be one of the biochemical markers indicating the severity of the disease.关键词
冠心病/N末端脑钠肽前体/血管成形术,经腔,经皮冠状动脉分类
医药卫生引用本文复制引用
刘雅,李志忠,温绍君,刘阔,楼煜清,刘洁琳,王佐广,文杰,严山,牛秋丽,顾伟..冠心病经皮冠脉介入治疗患者N末端脑钠肽前体水平与冠脉病变严重程度的相关性研究[J].中国全科医学,2011,14(16):1785-1788,4.基金项目
国家科技支撑计划(2008BAI52B03) （2008BAI52B03）
国家高技术研究发展计划(863计划)(2008AA02Z441) （863计划）
