西安交通大学学报（医学版）2011，Vol.32Issue(3)：275-278,4.
唐可肽对糖尿病大鼠血脂及脂质过氧化作用的影响
The effects of Tangketai on lipid level and lipid peroxidation in diabetic rats
屠霞 1王振林 1焦小红1
作者信息
- 1. 西安交通大学医学院公共卫生学系,陕西西安,710061
- 折叠
摘要
Abstract
Objective To observe the effects of Tangketai on lipid level and lipid peroxidation in diabetic rats. Methods Diabetic rat model was duplicated with fat- and sugar-rich diet and streptozotocin. Totally 37 rats with diabetes were divided into 4 groups, the diabetic model group and the low-, medium- and high-dose treatment groups. In addition, other normal SD rats served as controls. The diabetic rats in the treatment groups had been fed with Tangketai for eight weeks, and then had their levels of serum lipids, antioxidant enzymes and peroxidative products determined. The morphological changes in their livers were observed. Results The serum levels of triglyceride (TG), free fatty acids (FFA) and malondialdehyde (MDA) were significantly lower in the treatment groups than in the diabetic model group (P ＜ 0.05). Compared with the diabetic model group, there was a significant increase in serum superoxide diamutase (SOD) and glutathione peroxidase (GSH-Px) and a significant decrease in serum total cholesterol (TC) in the medium- and high-dose treatment groups (P＜0.05). Low-density lipoprotein cholesterol (LDL-C) significantly decreased and high-density lipoprotein cholesterol (HDL-C)significantly increased in the high-dose treatment group compared with those in the diabetic model group (P ＜0.05). Tangketai of different dosage had relieving effects of different degree on liver fatty degeneration of the diabetic rats. Conclusion Tangketai can regulate lipid metabolism, enhance the capability of anti-lipid peroxidation and improve liver steatosis of diabetic rats.关键词
糖尿病/血脂/脂质过氧化/唐可肽/脂代谢分类
医药卫生引用本文复制引用
屠霞,王振林,焦小红..唐可肽对糖尿病大鼠血脂及脂质过氧化作用的影响[J].西安交通大学学报（医学版）,2011,32(3):275-278,4.
