摘要
Abstract
Objective By measuring the bone mineral density ( BMD ) and bone metabolic markers in elderly male patients with chronic obstructive pulmonary disease ( COPD ), to explore the relationship between COPD and osteoporosis.Methods Totally 203 COPD male patients and 40 healthy controls of the same sex were recruited as the research objects.The bone mineral density ( by Dual - energy X - ray bone mineral density detection instrument ), serum calcium, phosphorus, magnesium, alkaline phosphatase ( T- ALP ), parathyroid stimulated ( PTH ), fasting urinary calcium and creatinine ratio ( Ca/Cr ), tartrate - resistant acid phosphatase ( TRAP ), osteocalcin ( GBP ) and other bone metabolic markers were measured and analyzed.Results ( 1 ) BMD at L1, L3 and L4 , as well as the Neck, GT, and InterTro of the hip of patients with COPD were significantly lower than those in controls ( P ＜ 0.05 ).The BMD values of COPD patients who Inhaled corticosteroids were significantly lower than those of COPD patients who did not inhale corticosteroids only at the L2 and the Neck of the hip ( P ＜ 0.05 ).( 2 ) Serum calcium, phosphorus, and T 鈥?ALP activity levels were not significantly different ( P ＞ 0.05 ), while the serum magnesium, PTH, TRAP, and Ca/Cr ratio were significantly different ( P ＜0.05 ) in COPD patients and controls.Compared with COPD patients who did not inhale corticosteroids, the patients who inhaled corticosteroids had decreased levels of magnesium and BGP, and increased values of TRAP and Ca/Cr ( P ＜0.05 ).( 3 ) The value of BMD at L3 and L4 , as well the Neck and GT of the hip of COPD patients was negatively correlated with duration of corticosteroid therapy ( r = - 0.69, - 0.38, - 0.46, -0.54, respectively, and P＜0.05).Conclusion The level of BMD in Elderly male patients with COPD patients is lower than that in healthy people with the same age.And the BMD change shows no significant difference between COPD patients who inhale corticosteroids and those who do not inhaled.However the Indices of bone absorption increase and the Indices of bone formation decrease in COPD patients who inhaled corticosteroids.关键词
慢性阻塞性肺疾病/骨质疏松/骨密度/糖皮质激素类分类
医药卫生
