中国全科医学2011，Vol.14Issue(16)：1812-1814,3.
联合免疫对阻断乙肝病毒母婴垂直传播的疗效研究
Efficacy of Hepatitis B Immunoglobulin (HBIG) Combined with Hepatitis B Vaccine in HbsAg+/HBV-DNA+ Pregnant Women
刘佩芝 1詹爱琴 1王英红 1张红 1李莎 1王萍2
作者信息
- 1. 832000,新疆维吾尔自治区石河子市,石河子大学医学院第一附属医院
- 2. 石河子妇幼保健院
- 折叠
摘要
Abstract
Objective To explore the efficacy of hepatitis B immunoglobulin ( HBIG ) combined with hepatitis B vaccine in HBsAg + /HBV - DNA + pregnant women.Methods A total of 228 HBsAg + /HBV - DNA + pregnant women were divided into four groups: groups A received 20 μg of hepatitis B vaccine on the 26th, 30th, and 34th gestational week; group B received 200 IU of HBIG on the 26th, 30th, and 34th gestational week; group C received 20 μg of hepatitis B vaccine on the 26th, 30th, and 34th gestational week and 200 IU of HBIG on their 28th, 32nd, and 36th gestational week; and Group D, as a control group, received neither HBIG nor hepatitis B vaccine injection.All the newborns from these mothers received 200 IU of HBIG both within 6 hours and 2 weeks after birth and were vaccinated against Hepatitis B 1 month, 2 months, and 7 months after birth via routine follow - up.Results The intrauterine infection rates of HBV were 7.8％ , 14.0％ , 7.7％ and 29.0％ in these four groups, respectively.HBsAg positive rates among newborns were significantly lower in groups A, B, and C than in group D ( P ＜ 0.05 ), but showed no statistical difference among the former three groups ( P ＞ 0.05 ).The positive rate of anti — HBsAg was significantly higher in group A ( 86.3％ ), group B ( 82.0％ ), and group C ( 89.2％ ) than in group D ( 62.9％ ) ( P ＜0.05 ).The positive rate of anti - HBsAg in newborns were not statistically different among these four groups ( P ＞0.05 ).Conclusion Hepatitis B immunoglobulin ( HBIG ) combined with hepatitis B vaccine is effective in preventing intrauterine infection among HBsAg + /HBV - DNA + pregnant women.关键词
肝炎病毒,乙型/免疫球蛋白类/疫苗分类
医药卫生引用本文复制引用
刘佩芝,詹爱琴,王英红,张红,李莎,王萍..联合免疫对阻断乙肝病毒母婴垂直传播的疗效研究[J].中国全科医学,2011,14(16):1812-1814,3.
