中国康复理论与实践2011，Vol.17Issue(3)：232-234,3.
大鼠脑多梗死性痴呆模型的建立
Establishing the Rat Model of Multi-infarct Dementia
摘要
Abstract
Objective To establish the rat model of multi-infarct dementia.Methods Sephadex (4 mg/ml, 8 mg/ml) was injected into the internal carotid artery through the common carotid artery.Neurological deficits were measured 24 h after the operation,and Morris water maze test as well as Nissl stain were observed 26～30 d after the operation.Results There was significant difference between the model groups injected sephadex of 8 ml/ml and 4 mg/ml in the neurologic deficits.In the following experiment, the rats injected sephadex of 8 mg/ml were only used as model.For the water maze test, the escape latency was longer (P＜0.01) and the frequency across target area reduced (P＜0.01) in the model, while the apoptotic Nissl body could be observed.Conclusion A model of multi-infarct dementia could be established with the sephadex in rats.关键词
多梗死性痴呆/葡聚糖凝胶/模型/大鼠分类
医药卫生引用本文复制引用
武冬慧,胡金凤,李志鹏,吉海杰,陈乃宏..大鼠脑多梗死性痴呆模型的建立[J].中国康复理论与实践,2011,17(3):232-234,3.基金项目
1.国家自然科学基金重点项目(No.30973887、No.U832008) （No.30973887、No.U832008）
2.创新药物研究开发技术平台建设(No.2009ZX09303、No.2009ZX09301). （No.2009ZX09303、No.2009ZX09301）
