首页|期刊导航|中国神经再生研究（英文版）|Preventive administration of cromakalim reduces aquaporin-4 expression and blood-brain barrier permeability in a rat model of cerebral ischemia/reperfusion injury
中国神经再生研究（英文版）2011，Vol.6Issue(13)：1005-1009,5.DOI:10.3969/j.issn.1673-5374.2011.13.008
Preventive administration of cromakalim reduces aquaporin-4 expression and blood-brain barrier permeability in a rat model of cerebral ischemia/reperfusion injury
Preventive administration of cromakalim reduces aquaporin-4 expression and blood-brain barrier permeability in a rat model of cerebral ischemia/reperfusion injury
摘要
Abstract
Cromakalim, an adenosine triphosphate-sensitive potassium channel opener, exhibits protective effects on cerebral ischemia/reperfusion injury. However, there is controversy as to whether this effect is associated with aquaporin-4 and blood-brain barrier permeability. Immunohistochemistry results show that preventive administration of cromakalim decreased aquaporin-4 and IgG protein expression in rats with ischemia/reperfusion injury; it also reduced blood-brain barrier permeability, and alleviated brain edema, ultimately providing neuroprotection.关键词
cerebral ischemia/reperfusion/cromakalim/aquaporin-4/blood-brain barrier/brain edemaKey words
cerebral ischemia/reperfusion/cromakalim/aquaporin-4/blood-brain barrier/brain edema引用本文复制引用
Shilei Wang,Yanting Wang,Yan Jiang,Qingxian Chang,Peng Wang,Shiduan Wang..Preventive administration of cromakalim reduces aquaporin-4 expression and blood-brain barrier permeability in a rat model of cerebral ischemia/reperfusion injury[J].中国神经再生研究（英文版）,2011,6(13):1005-1009,5.基金项目
the Shandong Provincial Science and Technology Program,No.2006GG202004 （）
