中国神经再生研究（英文版）2011，Vol.6Issue(13)：1010-1016,7.DOI:10.3969/j.issn.1673-5374.2011.13.009
Expression of fibroblast growth factor-2 and fibroblast growth factor receptor-1 protein in the hippocampus in rats exhibiting chronic stress-induced depression
Expression of fibroblast growth factor-2 and fibroblast growth factor receptor-1 protein in the hippocampus in rats exhibiting chronic stress-induced depression
Gonglin Hou 1Mingming Tang1
作者信息
摘要
Abstract
There is evidence that the expression of members of the fibroblast growth factor (FGF) protein family is altered in post-mortem brains of humans suffering from major depressive disorder. The present study examined whether the expression of fibroblast growth factor-2 (FGF2) and fibroblast growth factor receptor-1 (FGFR1) protein is altered following chronic stress in an animal model. Rats were exposed to 35 days of chronic unpredictable mild stress, and then tested using open-field and sucrose consumption tests. Compared with the control group, rats in the chronic stress group exhibited obvious depressive-like behaviors, including anhedonia, anxiety and decreased mobility. The results of western blot analysis and immunohistochemical analysis revealed a downregulation of the expression of FGF2 and FGFR1 in the hippocampus of rats, particularly in the CA1, CA3 and dentate gyrus. This decreased expression is in accord with the results of post-mortem studies in humans with major depressive disorder. These findings suggest that FGF2 and FGFR1 proteins participate in the pathophysiology of depressive-like behavior, and may play an important role in the mechanism of chronic stress-induced depression.关键词
depression/hippocampus/fibroblast growth factor-2/fibroblast growth factor receptor-1/neural regenerationKey words
depression/hippocampus/fibroblast growth factor-2/fibroblast growth factor receptor-1/neural regeneration引用本文复制引用
Gonglin Hou,Mingming Tang..Expression of fibroblast growth factor-2 and fibroblast growth factor receptor-1 protein in the hippocampus in rats exhibiting chronic stress-induced depression[J].中国神经再生研究（英文版）,2011,6(13):1010-1016,7.
