摘要
Abstract
Objective To observe the effect ot blood activating and cooling, stasis removing herbs on the occurrence rate of Henoch-Schonlein purpura nephritis (HSPN).Methods The 141 HSP children patients with bleeding of the blood stasis syndrome and of the blood heat syndrome ( having normal results of urine routines) were assigned to the blood activating and stasis removing group and the blood cooling and arresting group.They were treated with blood activating and stasis removing herbs and blood cooling and arresting herbs respectively for eight weeks.The occurrence rate and time of the renal injury, changes of transforming growth factor (TGF), Ddimer (D-D), immunoglobulin ( Ig), urine micro-protein, and urease before and after treatment were observed.Results The occurrence of the renal injury in the blood activating and stasis removing group was 36.2％, obviously lower than that in the blood cooling and arresting group (69.4％).The occurrence time of the renal injury was 32.2 ± 10.6 days, obviously later than that in the blood cooling and arresting group (20.0 ± 9.0 days),showing statistical difference ( P＜0.05).The levels of TGF, D-D, IgA, microglobulin (MG), immunoglobulin G(IgG), albuminuria (ALB) of children patients in the blood activating and stasis removing group were lower after treatment than before treatment, showing significant difference ( P ＜0.05 ).Significant difference was also shown when compared with those of the blood cooling and arresting group ( P ＜ 0.05).Conclusion The application of activating blood and removing stasis method could lower the probability of the renal injury in Henoch-Schonlein purpura (HSP).It played a role in preventing the occurrence of HSPN.关键词
过敏性紫癜肾炎/早期干预/活血化瘀/凉血止血Key words
Henoch-Schonlein purpura nephritis/ earty intervention/ activating blood and removing stasis/ blood coolding and arresting
