中国药房2011，Vol.22Issue(17)：1566-1568,3.
雷米普利拉和氯沙坦单用及联用对小鼠心肌缺血-再灌注损伤的心肌保护作用比较
Protective Effect of Ramiprilat or Losartan Alone and Their Combination against Myocardium Ischemia-reperfusion Injury in Mice
冉玉华 1刘新友2
作者信息
- 1. 第四军医大学附属唐都医院药剂科,西安市710033
- 2. 军事医学科学院毒物药物研究所心血管药理研究室,北京市100850
- 折叠
摘要
Abstract
OBJECTIVE: To observe the protective effect of ACEI ramiprilat or ARB losartan alone and their combination against myocardium ischemia-reperfusion injury in mice. METHODS: 32 C57BL/6 mice were randomly divided into four groups including control group (normal saline), losartan group (8 mg·kg-1), ramiprilat group (50 μg·kg-1) and losartan+ramiprilat (8 mg·kg-1+50 μg· kg-1) group. Myocardium ischemia-reperfusion injury model was established by intravenous push for 5 min before reperfusion. Physiological index were monitored during the process, such as arterial pressure, LVW/BW, AR/LV and heart rate. Mice were sacrificed and brain tissue was observed by staining using IS/AR as index. RESULTS: There were no significant differences in arterial pressure, LVW/BW, AR/LV and heart rate. IS/AR of ramiprilat or losartan alone and their combination were (21.8 ±2.3)％, (20.8 ± 3.2)％ and (18.4 ± 2.4)％, respectively, which is significant different from (39.6 ± 2.0)％ of control group (P＜0.05). There was no significant difference between single therapy group and combination therapy group. CONCLUSION: Ramiprilat and losartan have protective effect against myocardium ischemia-reperfusion injury. But combination therapy is not prior to single therapy.关键词
氯沙坦/雷米普利拉/心肌缺血.再灌注损伤/小鼠/心肌保护分类
医药卫生引用本文复制引用
冉玉华,刘新友..雷米普利拉和氯沙坦单用及联用对小鼠心肌缺血-再灌注损伤的心肌保护作用比较[J].中国药房,2011,22(17):1566-1568,3.
