中国药房2011，Vol.22Issue(17)：1602-1603,2.
国产与进口尼莫地平片的溶出度考察
Study on the Dissolution of Domestic and Imported Nimodipine Tablets
金丽 1张晓丹 1古卓良 1周国华1
作者信息
- 1. 南京军区联勤部药品仪器检验所,南京市210002
- 折叠
摘要
Abstract
OBJECTIVE: To study the dissolution of domestic and foreign Nimodipine tablets, and to provide reference for the quality improvement of domestic preparations. METHODS: According to the standard stated in Chinese Pharmacopoeia (2005 edition), the dissolution curve of Nimodipine tablets from domestic pharmaceutical factories (B, C, D, E) and foreign pharmaceutical factory (A) were determined by fiber-optic real-time dissolution test system. RESULTS: The dissolution rates of Nimodipine tablets in 30 min from five pharmaceutical factories met the requirements of Chinese Pharmacopoeia (2005 edition). The average dissolution percentages of Nimodipine tablets from five pharmaceutical factories were all more than 89 ％ while the dissolution rates were different. The average dissolution rates of Nimodipine tablets at 6 min from pharmaceutical factory A, B, C, D, E were 29.22％, 46.83％, 55.10％, 71.84％ and 45.72％, respectively. CONCLUSION: There is a significant difference in dissolution process between domestic and imported Nimodipine tablets. Domestic pharmaceutical factories should improve preparation technology and control the dissolution rate of drugs.关键词
尼莫地平片/溶出度/考察/实时溶出曲线/光纤药物溶出度实时测定仪分类
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金丽,张晓丹,古卓良,周国华..国产与进口尼莫地平片的溶出度考察[J].中国药房,2011,22(17):1602-1603,2.
