中国人兽共患病学报2011，Vol.27Issue(4)：316-319,324,5.
抗急性弓形虫病药物疗效的研究
Efficacy on different kinds of drugs against acute murine toxoplasmosis
摘要
Abstract
In order to identify more effective and less toxic drugs to treat animal toxoplasmosis, nine different kinds of drugs against T. gondii in an acute murine model were evaluated respectively. Then, the efficacy of the ideal drug SPZ was evaluated further through the different dosage and being combined with PM. The mice used throughout the study were randomly assigned to many groups (12 mice each), which either remained uninfected or were infected intraperitoneally with tachyzoites of T. gondii (strains RH, 5 000 organisms). Of 24 hours after infection, mice were administered with drugs at a moderate dosage for 5 days, according to the animal's body weight. Mice were observed for 40 days after infection. The factors of average survival days, time-point of 50％ fatalities and survival rate showed the efficacy of drugs. The results indicated that SPZ was the best drug against the parasites with better data compared with other drugs groups (P＜0. 05). Also, it showed SPZ (250mg/kg) and the combination of SPZ (350mg/kg) and PM (15mg/kg) protected almost 58.33％ and 54.55％ mice from death respectively. The average survival time and the time-point of 50％ fatalities were prolonged significantly compared to SD group and other treated groups (P＜0.05). The results suggest that SPZ seems to be a more efficacious drug in the treatment of T. gondii in an acute murine model. The drug may be a promising drug candidate for the treatment and prevention of toxoplasmosis in animals and lay a foundation for further research.关键词
弓形虫病/弓形虫/磺胺氯吡嗪分类
农业科技引用本文复制引用
曾艳波,朱顺海,韩红玉,董辉,姜连连,赵其平,马卫娇,程军,黄兵..抗急性弓形虫病药物疗效的研究[J].中国人兽共患病学报,2011,27(4):316-319,324,5.基金项目
农业公益性行业科研专项(No.200803017) （No.200803017）
