南京医科大学学报（自然科学版）2011，Vol.31Issue(4)：483-486,4.
淋巴细胞中POT1mRNA表达、端粒酶活性与2型糖尿病发生发展的关系
Relationship of POT1 mRNA expression,telomerase activity and development of type 2 diabetes
摘要
Abstract
Objective:To study the relationship of protection of telomeres 1 (POT1) mRNA expression,telomerase activity in lymphocytes with the development of type 2 diabetic mellitus (T2DM). Methods:One hundred and sixty-two cases with T2DM were test group, 162 cases of healthy were control group, real-time quantitative PCR was used to analysis POT 1 mRNA expression, semi-quantitative TRAP-ELISA was used to analysis telomerase activity. Results:The expression of POT 1 mRNA and telomerase relatively activity in test group were obviously higher than those in control group(P ＜ 0.01 ). Meanwhile,the POT1 mRNA expression and telomerase activity were significantly higher in T2DM patients with passable or poor controlled blood glucose compared with controls(P ＜ 0.01 ), and they were also significantly higher in T2DM patients with different stage of diabetic retinopathy compared with controls (P ＜ 0.01 ),significant differences also existed among the patients whose time course of T2DM between 5 to 10 years or above 10 years and time course of T2DM less than 5 years or controls (P ＜ 0.01 ). Conclusion: POT1 mRNA expression and the telomerase activity were significantly increased with the progression of T2DM;they might be the important evidences in disease prognosis.关键词
POT1 mRNA/端粒酶活性/2型糖尿病/血糖控制/视网膜病变分期/病程Key words
POT1 mRNA/telomerase activity/ttpe 2 diabetic mellitus/glycemic control/retinopathy stage/course分类
医药卫生引用本文复制引用
袁荣高,杨留才,刘德军,李仕红,徐红涛..淋巴细胞中POT1mRNA表达、端粒酶活性与2型糖尿病发生发展的关系[J].南京医科大学学报（自然科学版）,2011,31(4):483-486,4.基金项目
盐城市科技发展计划项目(YK20080121) （YK20080121）
