南京医科大学学报（自然科学版）2011，Vol.31Issue(4)：549-552,575,5.
胸腺上皮源性肿瘤诱导微血管生成的预后意义
The prognostic value of thymic epithelial tumors inducing neoplastic angiogenesis
刘标 1陈伟群 1周俊东 2吴锦昌 2杨光2
作者信息
- 1. 南京医科大学附属苏州医院病理科,江苏,苏州,215001
- 2. 南京医科大学附属苏州医院肿瘤中心,江苏,苏州,215001
- 折叠
摘要
Abstract
Objective: To assess the correlation between neoplastic microvessel density(MVD) and a series of pathological characteristics and study the prognostic value in postoperative patients of thymic epithelial tumors. Methods: MVD in 66 cases of thymic epithelial tumor was evaluated by the expression of monoclonal CD34 antibody. Survival analysis of 62 patients with 16～178 months follow-up was calculated using the Kaplan-Meier method and differences in survival were analyzed using the log rank test. Results:There were no significant correlation between MVD and some pathological characteristics including the patients' age(P ＞ 0.05) and gender(P ＞ 0.05). Although bigger tumor(≥ 11.0 cm) developed higher MVD value,no significant difference was found compared with smaller tumor(＜l 1.0 cm). MVD values were significantly different among subtypes of WHO histological classifications(P ＜ 0.05)and clinical stages of Masaoka's staging system (P ＜ 0.01). No positive correlation was found between MVD value and the status whether the patients had paraneoplastic myasthenial gravis or not (P ＞ 0.05). The survival curves showed that the increased MVD,WHO histological classifications and Masaoka's staging system were valuable prognostic predictors of thymic epithelial tumors. Conclusion:Tumor angiogenic activity might play an important role in capsular and widely neighbouring invasion of thymic epithelial tumors. MVD together with WHO histological classifications and Masaoka's staging system seem to be more helpful for clinical prognostic estimation.关键词
胸腺上皮源性肿瘤/微血管密度/预后Key words
thymic epithelial tumor/ microvessel density/ prognosis分类
医药卫生引用本文复制引用
刘标,陈伟群,周俊东,吴锦昌,杨光..胸腺上皮源性肿瘤诱导微血管生成的预后意义[J].南京医科大学学报（自然科学版）,2011,31(4):549-552,575,5.
