陕西医学杂志2011，Vol.40Issue(4)：387-389,425,4.
灵芝多糖对阿尔茨海默病大鼠学习记忆和氧化应激的影响
Effect of ganoderma lucidum polysaccharides on learning and memory ability and oxygen stress of model rats with Alzheimer' s disease
摘要
Abstract
Objective : To observe the effect of Ganoderma lucidum polysaccharides on learning and memory ability and oxygen stress of model rats with Alzheimer's disease. Methods : 40 males SD rats were randomized into normal group, sham operation control group, model group and trearment group. The rats were injected bilaterally Aβ1～40 into the hippocampus to induce learning and memory dysfunction. 21 days after Administered medication of Ganoderma lucidum polysaccharide, the rats were placed into the Morris maze to test intelligence. Then Malonic dialdehyde (MDA)content and superoxide dismutase (SOD) activity in serum were detected by spectrophotometry. Results :Compared with normal group and sham operationcontrol group,MDA content in serum of model group was obviously increased, while SOD activity was obviously decreased.Compared with model group, cerebral MDA contents of GLP treatment group were obviously decreased,while SOD activities were obviously increased. Conclusion: Ganoderma lucidum polysaccharide can improve the learning and memory ability of the AD rats induced by Aβ1～40. GLP have strong function of anti free radical.关键词
阿尔茨海默病/治疗/灵芝多糖/超氧化物歧化酶/血液/丙二醛/血液/大鼠分类
医药卫生引用本文复制引用
晏涛,陈世保,徐蕾,杨丽,陈龙菊..灵芝多糖对阿尔茨海默病大鼠学习记忆和氧化应激的影响[J].陕西医学杂志,2011,40(4):387-389,425,4.基金项目
湖北医药学院硕士启动金项目(2006QDJ01) （2006QDJ01）
湖北医药学院学生科研项目(N0.2007XS14) （N0.2007XS14）
