中药材2011，Vol.34Issue(3)：343-346,4.
斑蝥酸钠对人胃癌裸鼠皮下移植瘤组织中血管生成作用的研究
Effect of Sodium Cantharidinate on the Angiogenesis of Nude Mice with Human Gastric Cancer
摘要
Abstract
Objective: To study the effect of sodium cantharidinate on the angiogenesis of nude mice with human gastric cancer.Methods: Nude mice xenograft models of human gastric cancer were established by injecting gastric carcinoma cell BGC823 into peritoneal. Expression of VEGF and MVD labeling by CD34 in human gastric cancer cells were measured by immunohistochemis-try. Results:Expression scores of VEGF in medium dose and high dose group with sodium cantharidinate treatment were lower than those in low dose and control group(P ＜0. 01 ). There was no significant difference between medium dose and high dose group or low dose and control group( P ＞0. 05 ). MVD values in medium and high dose group with sodium cantharidinate treatment were lower than those in low dose and control group( P ＜0. 01 ), but there was no significant difference between medium dose and high dose group( P ＞ 0. 05 ). Conclusions:sodium cantharidinate can inhibit the growth of the tumor by down-regulating VEGF expression of the tumour cell and the anglogenesis of the tumour.关键词
斑蝥酸钠/胃癌/裸鼠移植瘤/血管内皮生长因子/微血管密度分类
医药卫生引用本文复制引用
梁枫,王明艳,黄文斌,李爱剑..斑蝥酸钠对人胃癌裸鼠皮下移植瘤组织中血管生成作用的研究[J].中药材,2011,34(3):343-346,4.基金项目
安徽省教育厅自然科学研究项目(KJ20078201) （KJ20078201）
