肿瘤防治研究2011，Vol.38Issue(4)：377-379,3.DOI:10.3971/j.issn.1000-8578.2011.04.004
肝细胞生长因子对结肠癌细胞SW620增殖、侵袭的影响
Effects of Hepatocyte Growth Factor on Proliferation and Migration of Human Colon Cancer Cells SW620
摘要
Abstract
Objective To investigate the effects of Hepatocyte growth factor (HGF) on the proliferation and migration of SW620. Methods MTT was used to assess the effect of HGF on the proliferation of SW620. The effect of HGF on the migration of cells was calculated by restoration of basal membrane; the ultrastructure of SW620 after being treated with HGF was observed by TEM; the expression of MMP-2 was determined by PCR. Results HGF promoted both the proliferation and migration of SW620 in a dose-dependent manner. Microfilaments increased significantly after being treated with HGF. HGF up-regulated the expression level of MMP-2 mRNA of SW620 cells. Conclusion HGF can promote the proliferation and migration of colon cancer cell SW620.关键词
肝细胞生长因子/增殖/侵袭/结肠癌Key words
HGF/ Proliferation/ Migration/ Human colon cancer分类
医药卫生引用本文复制引用
贾漪涛,刘敏,王安峰,郭薇,张雷,李中信..肝细胞生长因子对结肠癌细胞SW620增殖、侵袭的影响[J].肿瘤防治研究,2011,38(4):377-379,3.基金项目
河北省博士基金资助项目(05547008D-3) （05547008D-3）
