肿瘤防治研究2011，Vol.38Issue(4)：411-415,5.DOI:10.3971/j.issn.1000-8578.2011.04.012
HGF、c-Met和VEGF-C在宫颈癌中的表达
Expression of HGF,c-Met and VEGF-C in Cervical Carcinoma
摘要
Abstract
Objective To investigate the expression level of hepatocyte growth factor(HGF) and its re ceptor, the proto-oncogene c-Met, and vascular endothelial growth factor-C(VEGF-C) in cervical car cinoma Methods The mRNA levels of HGF,c-Met and VEGF-C were detected by Real Time fluo rescence Quantitative PCR(FQ RT-PCR) method in 43 cervical carcinoma tissues,30 cervical intraepi thelial neoplasm Ⅲ (CINⅢ) tissues and 27 normal cervical, respectively. Results The positive expres sion of HGF mRNA, c-Met mRNA and VEGF-C mRNA increased remarkably from normal tissue to CINⅢ and then to cervical carcinoma (P＜0. 05). In cervical carcinoma, the expression of these three genes was positive correlated with the clinical stage, tumor size, the invasion of deep muscular layer and the lymph node metastasis(P＜0. 05). These three genes were significant positive correlation (P ＜0. 01). Conclusion Over expression of HGF, c-Met and VEGF-C together may participate in the invasion and metastasis of cervical carcinoma To investigate them together would be facilitated to the treatment and prognosis of cervical carcinoma.关键词
宫颈癌/肝细胞生长因子/c-Met/血管内皮生长因子CKey words
Cervical carcinoma/ HGF/ c-Met / VEGF-C分类
医药卫生引用本文复制引用
张雪玉,张咏梅,杨彩虹,刘莉莉,吴蔚..HGF、c-Met和VEGF-C在宫颈癌中的表达[J].肿瘤防治研究,2011,38(4):411-415,5.基金项目
宁夏自然科学基金资助项目(NZ08104 （）
NZ10144) （）
