摘要
Abstract
Objective To evaluate the effect and safety of gonadotrophin - releasing hormone agonist ( GnRH - α ) combined with estradiol valerate and medroxyprogesterone acetate in the treatment of endometriosis after conservative laparoscopic operation.Methods Thirty two patients with endometriosis were randomly divided into 2 groups after laparoscopic operation, with 16 patients on the second day of their period in group A receiving 3.75mg triptorelin once every 4 weeks, 12 weeks in all and 16 patients on the second day of their period in group B receiving triptorelin and added 1mg CA and 6mg oral medroxy progesterone acetate per day, 12 weeks in all.Serum E2, FSH, LH, CA125, visual analogue scale ( VAS ) of pain and the form of Kupperman were compared in patients before and after treatment.Results ( 1 ) After treatment, the levels of FSH, LH, E2 were ( 2.2 ±2.1 ) U/L, ( 1.70 ±0.61 ) U/L, ( 27.6 ±6.05 ) pg/ml in group A and ( 1.9 ± 1.4 ) U/L, ( 1.59 ±0.74 ) U/L, ( 39.5 ±9.01 ) pg/ml in group B respectively, and they were significantly lower than those before treatment ( P ＜0.05 ).The level of CA125 was significantly decreased compared with those before GnRH - α treatment ( P ＜0.01 ).( 2 ) Before the treatment, patients VAS scores of A and B group were ( 5.41 ±2.92 ) and ( 5.64 ± 3.17 ) respectively, they were significantly higher than the ( 2.03 ± 1.92 ) and ( 2.45 ± 2.06 ) after GnRH - α treatment ( P ＜ 0.01 ), however, no statistically significant difference was found between the two groups after treatment ( P ＞ 0.05 ).( 3 ) The form of Kupperman after treatment were ( 14.71 ±7.63 ) in group A and ( 11.13 ±6.54 ) in group B, the difference was not statistically significant ( P ＞0.05 ).The incidence of flash and sweat were 93.8％ in group A, which was significant higher than the 56.3％ in group B ( P ＜0.01 ).Conclusion The add - back therapy that consists of transdermal estradiol and medroxy progesterone acetate is effective and safe in the treatment for endometriosis.关键词
子宫内膜异位症/促性腺激素释放激素激动剂/药物疗法分类
医药卫生
