中国全科医学2011，Vol.14Issue(17)：1917-1919,3.
血管紧张素原基因启动子区A-20C和A-6G单核苷酸多态性与原发性高血压的相关性研究
Relationships between Mononucleotide Polymorphism of Angiotensinogen Gene at Promoter A-20C and A-6G and Primary Hypertension
龚洪涛 1郭一力 1杜凤和1
作者信息
- 1. 100050北京市,首都医科大学附属北京天坛医院心内科
- 折叠
摘要
Abstract
Objective To investigate the relationship between primary hypertension and mononucleotide polymorphism of A - 20C and A - 6G at the promoter region of angiotensinogen gene.Methods The study covered 200 hypertension patients and 192 normotensive controls.A - 20C and A - 6G polymorphism of the AGT gene was determined using polymerase chain reaction - Restriction fragment length polymorphism ( PCR - PFLP ).Biochemical indices such as serum glucose ( GLU ) and total cholesterol ( TC ), triglyceride ( TG ), high density lipoprotein ( HDL ) and low density lipoprotein ( LDL ) were also measured.Results There was no significant difference between the two groups in terms of A - 20C genotype ( x2=2.226, P=0.136; x2 = 1.78, P =0.182 ) There was no significant difference between the two groups in terms of.A -6G genotype ( x2 =0.012, P = 0.911; x =0.052, P=0.82).Conclusion There was no correlation between A - 20C and A - 6G polymorphisms of AGT gene and primary hypertention.关键词
血管紧张素原/原发性高血压/基因多态性分类
医药卫生引用本文复制引用
龚洪涛,郭一力,杜凤和..血管紧张素原基因启动子区A-20C和A-6G单核苷酸多态性与原发性高血压的相关性研究[J].中国全科医学,2011,14(17):1917-1919,3.
