中国全科医学2011，Vol.14Issue(17)：1964-1965,2.
阿立哌唑治疗脑卒中后抑郁的疗效及其对事件相关电位P300的影响
Efficacy and Effects on P300 Event-related Potentials of Aripiprazole in Patients with Depression after Stroke
摘要
Abstract
Objective To explore the curative effect of aripiprazole on depression after stroke and compare it with per-phenazine.Methods A total of 64 cases of depression after stroke were randomized into observation groups and control group, 32 cases each.Both groups received supportive treatment routinely, with oral administered aripiprazole 5～ 15mg/d for the observation group and perphenazine 4 ～ 20mg/d for the control group.No other antipsychotic drugs were used during the 8 - week treatmeng.Curative effect and variation in latent period and amplitude of event related potential P300 of the two groups were compared.Results Of the 32 patients in the observation group, 13 were cured, 7 had been largely improved, 8 showed improvement , 4 showed no response by the end of 8th week; of the 32 patients in the control group 7 were cured, 5 had been largely improved, 7 showed improvement, 13 showed no response by the end of 8th week.Curative effects between the two groups showed statistically significant differences ( u = 2.42, P ＜ 0.05 ).Latent period length [( 348.9 ± 16.5 ) ms vs.( 357.3 ± 1.45 ) ms]and amplitude [( 7.9 ± 2.4 ) μV vs.( 6.7 ± 2.0 ) μV J of P300 showed significant difference between the observation group and the control group by the end of 8th week ( P ＜ 0.05 ).HAMD score for the observation group and the control group were ( 13.9 ± 3.2 ) and ( 17.2 ±4.7 ) respectively by the end of 8th week ( P ＜0.05 ).Conclusion Aripiprazole is more effective in treatment of depression after stroke than perphenazine.关键词
阿立哌唑/卒中/抑郁/事件相关电位,P300分类
医药卫生引用本文复制引用
吴美娟,甘建光,蒋荣泉,钱蠡..阿立哌唑治疗脑卒中后抑郁的疗效及其对事件相关电位P300的影响[J].中国全科医学,2011,14(17):1964-1965,2.
