中国肺癌杂志2011，Vol.14Issue(4)：329-334,6.DOI:10.3779/j.issn.1009-3419.2011.04.05
射波刀治疗31例晚期非小细胞肺癌患者的疗效观察
Preliminary Effect of Cyberknife Radiosurgery in the Treatment of 31 Patients with Advanced Non-small Cell Lung Cancer
摘要
Abstract
Background and objective Recently, Cyberknife is a new flame-less stereotactic radiation therapy technology, which has several advantages, such as large dose, high precision and minimizing exposure to the surrounding normal tissue or adjacent vital structures, so it is successful in the treatment of non-small cell lung cancer (NSCLC).Ihe aim of this study is to determine the effectiveness and safety of robotic stereotactic radiotherapy- Cyberknife with image guidance and realtime respiratory tracking against clinical stage Ⅲ-Ⅳ peripheral NSCLC.Methods A review of treatment details and outcomes for 31 patients, with 34 tumors with histologically proven cancers treated by Cyberknife at the CyberKnife Center of Nanjing general hospital of Nanjing military command between March 2009 and March 2010 is presented.Of the 3lpatients, 15 were adenocarcinoma and 12 were squamous cell cancer.Twenty-eight patients received other forms of antineoplastic therapy such as chemotherapy.A total dose of 36 Gy-60 Gy was prescribed to the 65％-85％ isodose line and given in two to five fractions in less than 1 week using the CyberKnife radiosurgery system.CT scans were performed after one-two months, then patients were followed every 3 months.Results Two patients had complete radiographic responses, l6 patients showed PRs, 7 patients showed SDs.Two patients showed PRs (reduction in tumor size), but developed distant metastases.Response rate was 58％and disease control rate was 81％.All patients tolerated the radiosurgery well, fatigue being the main side effect.No grade 4 or above toxicity was encountered.Conclusion In this small cohort of patients with advanced peripheral NSCLC, Cyberknife seems to be a safe and has good therapeutic effects with slight adverse reaction, but long time follow-up is necessary to evaluate the survival data and late toxicity.关键词
射波刀/立体定向放射治疗/肺肿瘤Key words
Cyberknife/ Stereotactic radiotherapy/ Lung neoplasms分类
医药卫生引用本文复制引用
吕艳玲,王振,朱锡旭,沈泽天,袁冬梅,缪小辉,施毅,宋勇..射波刀治疗31例晚期非小细胞肺癌患者的疗效观察[J].中国肺癌杂志,2011,14(4):329-334,6.基金项目
本研究受江苏省自然科学基金(No.BK2008326)和江苏省医学重点人才基金(No.RC2007113)资助 （No.BK2008326）
