摘要
Abstract
Objective To investigate the effect of Shenling decoction against drug-induced gastric mucosa injury in adjuvant arthritis(AA) rats. Methods The complex rat models of AA and drug damage were rendered. After 2 times of reaction, 48 rat models were randomly selected and divided into 7 groups: model group, compound model group, Ranitidine group,Shenling decoction low-dose group, Shenling decoction middle-dose group, Shenling decoction high-dose group, and blank control group (8 each ). Ranitidine group underwent intragastric administration treatment with Ranitidine at a dosage of 30 mg/( kg · d), and Shenling decoction low-dose group, Shenling decoction middle-dose group, Shenling decoction high-dose group underwent intragastric administration treatment with Shenling decoction at different doses of 3.5 g, 7 g, 14 g/(kg · d) respectively. Blank control group, model group and compound model group were given isometric 0. 9％ sodium chloride injection. All the groups were treated for 14 days. Tumescence incident and index of foot and claw, and gastric mucosa injury index and inhibition ratio, and the pathologic changes were compared before and after treatment. Results There was no significant difference in joint tumescence incidents and indexes among model group, compound model group, Ranitidine group and Shenling treatment groups before and after treatment(P ＞0.05). When compared with that in the blank control group, tumescence incident of foot and claw in the other groups showed significant difference before and after treatment(P ＜0. 05); the foot volume and arthritis index in the groups treated with Shenling decoction were lower than those in model group and compound model group without significant difference ( P ＞ 0. 05 ). When compared with that in the compound model group, the gastric mucosa danage index in Ranitidine group, Shenling decoction low-dose group, Shenling decoction middle-dose group, Shenling decoction high-dose group showed significant difference(P ＜ 0.01 ), but there was no significant difference among Shenling decoction middle-dose group, Shenling decoction high-dose group and Ranitidine group( P ＞ 0.05 ). There was significant difference of gastric mucosa damage index between Shenling decoction high-dose group and Ranitidine group (P ＜0.05). Inhibition ratios of gastric mucosa damage in Ranitidine group, Shenling decoction low-dose group, Shenling decoction middle-dose group, and Shenling decoction high-dose group were 74. 05％, 66. 81％, 74.41％, and 55.70％ respectively, and there ws significant difference among the groups( P ＜ 0. 05). Conclusion Shenling decoction has protective efficacy on the drug gastric mucosa injury without significant adverse effect on AA rat's joints.关键词
参灵方/大鼠,Wistar/关节炎,实验性/胃黏膜/创伤和损伤Key words
Shenling decoction/ Rat, Wistar/ Arthritis, experimental/ Gastric mucosa/ Wound and injury分类
医药卫生
