摘要
Abstract
Objective To investigate the difference of liver function and serum fibrosis markers between HbeAg positive and negative patients with hepatitis B. Methods 232 cases of hepatitis B were enrolled from January 2010 to December 2010, and were divided into HbeAg positive group and HbeAg negative group. The level of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), HBV-DNA, HA, and IV collagen (IV-C) were detected, and the relationship between the indicators and chronic liver disease was analyzed. Results ALT and HBV-DNA in HbeAg positive group were (429. 10 ± 178.49) U/L, (4.41 ± 0. 87) × 104 copy/nd, but (205.10 ± 85.55) U/L, (2. 38 ± 1.71 ) × 104 copy/ml in HbeAgnegative group, there was significant difference between the two groups ( P ＜ 0. 01 ); AST, HA and IV-C in HbeAg positive group were (98.00 ±4.36)U/L, (145.00 ±32.65)μg/L, (327.80 ±60.43)μg/L respectively, but in HbeAg-negative group they were (96.58 ± 5.38 ) U/L, ( 135.00 ± 23.75 ) μg/L, ( 321.30 ± 35.09 ) μg/L, and there was no significant difference between the two groups ( P ＞ 0. 05 ). Conclusion Virus replicates actively in HbeAg positive patients, but both HbeAg positive and negative patients have a certain degree of liver damage and fibrosis. It is necessary to take regular checks for HbeAg-negative patients to control disease progression and to reduce the incidence of hepatic cirrhosis.关键词
肝炎,乙型/肝炎e抗原,乙型/病毒复制/肝硬化Key words
Hepatitis/ type B/ Hepatitis e antigen/ type B/ Virus Replication /Hepatic cirrhosis分类
医药卫生
