中国当代儿科杂志2011，Vol.13Issue(5)：365-369,5.
哌醋甲酯和托莫西汀治疗注意缺陷多动障碍的疗效与安全性的系统评价
Effectiveness and safety of methylphenidate and atomoxetine for attention deficit hyperactivity disorder:a systematic review
吕晓珍 1舒正 1张耀文 1武珊珊 1詹思延1
作者信息
- 1. 北京大学医学部公共卫生学院流行病与卫生统计学系/流行病学教育部重点实验室,北京100191
- 折叠
摘要
Abstract
Objective To assess and compare the effectiveness and safety of methylphenidate immediate-release tablets ( IR-MPH), methylphenidate controlled release tablets (OROS-MPH) and atomoxetine (AHC) for attention deficit hyperactivity disorder (ADHD) in Chinese children. Methods Randomized or clinical controlled trials on the effectiveness and safety of IR-MPH, OROS-MPH and AHC for ADHD were searched in electronic databases of CNKI,VIP, CBMDISC online, PubMed, Embase and MEDLINE. Two reviewers independently extracted the data and assessed the quality of the included literatures. Results Eight trials were finally included. IR-MPH, OROS-MPH and AHC were effective for ADHD. OROS-MPH was superior to IR-MPH in the improvement of peer relationship, CGI-I score, mother satisfaction and psychosomatic problems. There were no significant differences in the effectiveness between the AHC and IR-MPH groups. The adverse events related to the therapy with IR-MPH, OROS-MPH or AHC were mild and the incidence rates of adverse events were not significantly different among the three groups. Conclusions The effectiveness of OROSMPH for the treatment of ADHD is probably superior to IR-MPH, and the effectiveness between AHC and IR-MPH is similar. The three drugs demonstrate the safety and well tolerance.关键词
哌醋甲酯/托莫西汀/注意缺陷多动障碍/系统评价/儿童分类
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吕晓珍,舒正,张耀文,武珊珊,詹思延..哌醋甲酯和托莫西汀治疗注意缺陷多动障碍的疗效与安全性的系统评价[J].中国当代儿科杂志,2011,13(5):365-369,5.
