中国当代儿科杂志2011，Vol.13Issue(5)：373-376,4.
川崎病冠脉瘤患儿远期血管内皮功能的研究
Late endothelial function in children with coronary aneurysm due to Kawasaki disease
摘要
Abstract
Objective To evaluate the late endothelial function in children with coronary aneurysm due to Kawasaki disease (KD). Methods Thirty-one children with coronary aneurysms duc to KD who had the disease course for more than 1 year and twenty-one age-matched healthy children were enrolled. Brachial artery endothelium-dependent and -independent flow-mediated dilation (FMD), carotid arterial stiffness index (SI) and intima-media thickness (IMT) were measured by high-frequency ultrasound. Results There were 9 cases of medium and 22 cases of giant coronary aneurysms in the KD group. Twelve KD patients had evidence of myocardial ischemia. Compared to the normal controls, the endotheliumdependent FMD decreased (P ＜ 0. 05), the carotid arterial SI increased (P ＜ 0.05), and the carotid arterial intima-media thickness increased significantly (P ＜0.05) in children with coronary aneurysms due to KD. The endothelium-dependent FMD decreased more significantly in 12 KD patients with myocardial ischemia than in those without any evidence of myocardial ischemia (P ＜ O. 05 ). Conclusions Late endothelial dysfunction exists in children with coronary aneurysms due to KD, especially in those with myocardial ischemia.关键词
川崎病/冠脉瘤/血管内皮依赖性舒张功能/儿童分类
医药卫生引用本文复制引用
段超,杜忠东,王玉,贾立群..川崎病冠脉瘤患儿远期血管内皮功能的研究[J].中国当代儿科杂志,2011,13(5):373-376,4.基金项目
北京"首都医学发展科研基金"重点项目资助(2007-2063) （2007-2063）
国家自然基金面上项目(30973238) （30973238）
北京自然科学基金面上项目(7092032) （7092032）
北京自然科学基金B类/北京教育委员会重大科研项目(KZ201010025024). （KZ201010025024）
