中国临床药理学与治疗学2011，Vol.16Issue(3)：300-303,4.
舒芬太尼与芬太尼用于全麻下脊柱矫形术中唤醒效果的比较
Comparison on wake-up time of sufentanil and fentanyl on intraoperative wake-up test in general anesthesia patients undergoing spinal correction surgery
吴礼平 1王文军 2彭建明 3高利臣4
作者信息
- 1. 湖南省马王堆医院麻醉科,长沙,410016,湖南
- 2. 南华大学附属第一医院脊柱外科,衡阳,421002,湖南
- 3. 南华大学附属第一医院麻醉科,衡阳,421002,湖南
- 4. 中南大学临床药理研究所,长沙,410078,湖南
- 折叠
摘要
Abstract
AIM: To research the effect of sufentanil and fentanyl on intraoperative wakeup time and quality in patients undergoing spinal correction surgery, and to study the operation method of intraoperatie wake-up test of spinal correction surgery, and further evaluate the effect of wake-up test. METHODS: Thirty eight cases of patients with spinal deformity were treated by spinal correction surgery. They were randomly divided into sufentanil group and fentanyl group with 19 patients in each group. The anesthesia induction was begun with intravenous infusion 0.1 mg/kg midazolam, 1.5-2.0 mg/kg propofol, 0. 15-0.20 mg/kg atracurium and 0.2 μg/kg sufentanil or 4.0μg/kg fentanyl. The anesthesia was maintained with continuous pump injection sufentanil 0.1 μg/(kg · h) or fentanyl 1 μg/(kg · h). Atracurium, sufentanil or fentanyl were stopped pump injection in the time of 30 min before needing awakening. The pump injection of propofol in the time of need awakening was stopped, and the process of waking up was begun. The wake-up time and quality were studied. RESULTS: The gender, age, weight and operation time were no statistically significant differences between sufentanil group and fentanyl group during the research. The recovery time of spontaneous breathing, open eyes, instruction moves of sufentanil group were shorter than fentanyl group (P＜ 0.05). The wake-up quality of sufentanil group was better than fentanyl group (P＜0.05). There was 1 case of patients with intraoperative pain and awareness in fentanyl group. Both groups had no other complications. CONCLUSION: This method of intraoperative wake-up test is fast and effective. The wake-up time of the anesthesia which used sufentanil is shorter than those of fentanyl group, and the wake-up quality is higher than the later.关键词
舒芬太尼/芬太尼/脊柱矫形术/全身麻醉/唤醒试验Key words
Sufentanil/ Fentanyl/ Spinal Correction Surgery/ General Anesthesia/ Wake-up Test分类
医药卫生引用本文复制引用
吴礼平,王文军,彭建明,高利臣..舒芬太尼与芬太尼用于全麻下脊柱矫形术中唤醒效果的比较[J].中国临床药理学与治疗学,2011,16(3):300-303,4.
