国际医药卫生导报2011，Vol.17Issue(9)：1050-1053,4.DOI:10.3760/cma.j.issn.1007-1245.2011.09.011
复发性生殖器疱疹细胞免疫与治疗的相关性研究
Relationship of cell-mediated immunity with treatment in recurrent genital herpes FAN
摘要
Abstract
Objective To observe the therapy efficacy in patients with recurrent genital herpes (RGH)via the detection of the change in peripheral blood T-lymphocyte subpopulation,and to explore the related mechanisms of cell-mediated immunity.Methods 52 patients received a 4-course thempy with oral famciclovir of 250mg,thrice daily for 5 days and an injection of thymopentin of 1 mg once daily for 15days.T-lymphocyte subpopulation(CD3+.CD4+.CD8+,and CD4+/CD8+)was detected by flow cytometry before and after treament.The results were then compared those from the healthy controls.Results As compared with those the control group,CD3+.CD4+.and CD46/CD8+were decreased and CD8+was increased in the treatment group,with a statistical difference between the two groups(P＜0.01 ). After a 2-month therapy with antiviral drugs and immunomodulators,CD3+.CD4+ and CD4+/CD8+ elevated and CDs+declined.There was a statistical difference after treatment(P＜0.01). Before treatment,each patient had flare-up 4.5 times annually on average,but only 1.5 times after treatment,with a statistical difference(P ＜0.05). Conclusions Cellular immune dysfunction may occur in patients with RGH.Therapy with antiviral drugs and immunomodulators can improve cell-mediated immunity in the patients,and reduce the recurrence of genital herpes.关键词
复发性生殖器疱疹/细胞免疫/治疗Key words
Recurrent genital herpes/Cell-mediated immunity/Treatment引用本文复制引用
范妙玲,刘炼庆,李科伦,邓文全..复发性生殖器疱疹细胞免疫与治疗的相关性研究[J].国际医药卫生导报,2011,17(9):1050-1053,4.
