中国神经再生研究（英文版）2011，Vol.6Issue(14)：1086-1090,5.DOI:10.3969/j.issn.1673-5374.2011.14.009
Effect of propofol pretreatment on apoptosis in rat brain cortex after focal cerebral ischemia and reperfusion
Effect of propofol pretreatment on apoptosis in rat brain cortex after focal cerebral ischemia and reperfusion
Haiyan Xu 1Chengwei Zhang 1Chunxiao Zhang1
作者信息
摘要
Abstract
The present study aimed to observe cortical expression of Bcl-2 and Bax, cysteine-dependent aspartate directed proteases-3 activity and apoptotic cell death in a rat model of middle cerebral artery occlusion pretreated with propofol. Results showed that, propofol pretreatment significantly reduced oxidative stress levels and attenuated neuronal apoptosis in the cortex of rats. Propofol pretreatment upregulated Bcl-2 expression, and downregulated Bax expression and cysteine-dependent aspartate directed proteases-3 activity. These findings indicate that propofol pretreatment inhibits cell apoptosis during focal cerebral ischemia/reperfusion injury. This neuroprotective effect is most likely achieved through the Bcl-2/Bax/cysteine-dependent aspartate directed proteases-3 pathway.关键词
propofol/cerebral ischemia/reperfusion/apoptosis/neuroprotection/neural regenerationKey words
propofol/cerebral ischemia/reperfusion/apoptosis/neuroprotection/neural regeneration引用本文复制引用
Haiyan Xu,Chengwei Zhang,Chunxiao Zhang..Effect of propofol pretreatment on apoptosis in rat brain cortex after focal cerebral ischemia and reperfusion[J].中国神经再生研究（英文版）,2011,6(14):1086-1090,5.
