首页|期刊导航|中国神经再生研究（英文版）|Gentianine protects hippocampal neurons in a rat model of recurrent febrile convulsion
中国神经再生研究（英文版）2011，Vol.6Issue(15)：1130-1135,6.DOI:10.3969/j.issn.1673-5374.2011.15.002
Gentianine protects hippocampal neurons in a rat model of recurrent febrile convulsion
Gentianine protects hippocampal neurons in a rat model of recurrent febrile convulsion
摘要
Abstract
Gentianine has been shown to have a protective effect on hippocampal CA1 neurons in rats subjected to recurrent febrile convulsion (FC).The present study sought to explore the possible mechanism of gentianine by intraperitoneally injecting gentianine into rats with warm water-induced FC.The results revealed that neuronal organelle injury was slightly ameliorated in the hippocampal CA1 region.The level of glutamate was decreased,but the level of γ-aminobutyric acid was increased,as detected by ninhydrin staining.In addition,glutamate acid decarboxylase expression in hippocampal CA1 was increased,as determined by immunohistochemistry.The results demonstrated that gentianine can ameliorate FC-induced neuronal injury by enhancing glutamate acid decarboxylase activity,decreasing glutamate levels and increasing γ-aminobutyric acid levels.关键词
febrile convulsion/gentianine/hippocampal neurons/neuroprotective effect/glutamate/γ-aminobutyric acid/neural regenerationKey words
febrile convulsion/gentianine/hippocampal neurons/neuroprotective effect/glutamate/γ-aminobutyric acid/neural regeneration引用本文复制引用
Xuewei Liu,Shumin Liu,Na Wang,Fang Lu,Min Cao..Gentianine protects hippocampal neurons in a rat model of recurrent febrile convulsion[J].中国神经再生研究（英文版）,2011,6(15):1130-1135,6.基金项目
the Key Project of Technology,Ministry of Education (Effects and mechanism of gentianine on febrile convulsion in rats),No.2007029. （Effects and mechanism of gentianine on febrile convulsion in rats）
