疑难病杂志2011，Vol.10Issue(7)：515-516,2.DOI:10.3969/j.issn.1671-6450.2011.07.016
雌激素受体、孕激素受体及增殖细胞核抗原在子宫内膜癌中的表达及意义
Expressions and clinical significance of ER,PR and PCNA in endometrial Adenocarcinoma
郑晓霞 1张宁 1郭伟男 1翟雨佳 2李梦轩 1苏军领1
作者信息
- 1. 050800,河北省正定县人民医院妇科
- 2. 050800,河北省正定县人民医院病理科
- 折叠
摘要
Abstract
Objective To investigate the expression of ER, PR and PCNA in endometrial adenocarcinoma.Methods Immunohistochemical staining SP method was used to detect the expression of ER, PR and PCNA in 25 cases of normal proliferative endometrium, 25 cases of atypical endometrial hyperplasia, and 40 cases of endometrial adenocarcinoma.Results The expression of ER and PR in norm al proliferative endometrium, atypical endometrial hyperplasia and endometrial adenocarcinoma were decreased gradually( P ＜ 0.05 ).Further study showed that there were associations between expressions of them and cell differentiation in endometrial adenocarcinoma( P ＜ 0.05 ), but not with the surgery pathological stage( P ＞ 0.05 ).The expression of PCNA in norm al proliferative endometrium, atypical endometrial hyperplasia and endometrial adenocarcinoma were increased gradually( P ＜ 0.05 ), and the expression was associate with the cell differentiation in endometrial adenocarcinoma( P ＜0.05 ).Negative correlation was found among ER, PR and PCNA expression( r = -0.361, r = -0.441 respectively, P ＜ 0.05 ).Conclusion Abnormal expression of ER, PR and PCNA may contribute to the pathogenesis and development of the endometrial adenocarcinoma.There expression may provide imformation for clinic in choosing endocrine therapy.关键词
子宫内膜癌/雌激素受体/孕激素受体/增殖细胞核抗原Key words
Endometrial adenocarcinoma/Estrogen receptor/Progesterone receptor/Proliferating cell nuclear antigen引用本文复制引用
郑晓霞,张宁,郭伟男,翟雨佳,李梦轩,苏军领..雌激素受体、孕激素受体及增殖细胞核抗原在子宫内膜癌中的表达及意义[J].疑难病杂志,2011,10(7):515-516,2.
