广东医学2011，Vol.32Issue(11)：1399-1401,3.
米诺环素对脑缺血再灌注损伤后炎性反应的影响
Effects of minocycline on brain inflammation of rat focal cerebral ischemia-reperfusion injury
摘要
Abstract
Objective To study the effects of minocycline on brain inflammatory response of focal cerebral ischemia reperfusion injury in rats. Methods Sprague - Dawley rats were randomly divided into sham - operation group, control group, minocycline preconditioning group, 30 min group and 4 h group. Focal cerebral ischemia was produced by introduction of intraluminal nylon in rats. The expression of cyclooxygenase - 2 ( COX - 2 ), interleukin - 1β converting enzyme ( ICE ) and prostaglandin E2( PGE2 ) was assessed with immunohistochemistry, reverse transcription polymerase chain reaction and radioimmunity. Meanwhile, MRI was performed to assess focal ischemia area in rat brains. Results Minocycline significantly reduced the expression of COX - 2, ICE and PGE2 , and facol ischemia area in the brains of rats ( P ＜ 0. 05 ). Conclusion Minocycline inhibits brain inflammation of rat cerebral ischemia - reperfusion injury.关键词
米诺环素/脑缺血再灌注/炎性反应Key words
minlcycline/ cerebral ischemia - reperfusion/ inflammatory response引用本文复制引用
熊建忠,易飞,陆兵勋..米诺环素对脑缺血再灌注损伤后炎性反应的影响[J].广东医学,2011,32(11):1399-1401,3.基金项目
江西省科学技术专项基金项目(编号:2010BSB01800) （编号:2010BSB01800）
